Malaria is endemic in 21 out of 25 provinces in Cambodia with peak transmission primarily in rainy seasons between June to November. Highest incidence rates occur in Northern Cambodia with malaria multidrug resistance occurring mainly in Western parts of Cambodia. Coordinated efforts by the National Malaria Program have reduced malaria morbidity and mortality rates in recent years. Cambodia is working to eliminate Pf by 2020 and become malaria-free by 2025. Since 2017, Pv malaria cases have been increasing predominantly while a radical cure still hasn’t been initiated. Current malaria control and elimination efforts include: improving prevention through the distribution of LLINs, strengthening EDAT particularly at the community level, effective surveillance system, and building national capacity in malaria research and program monitoring and evaluation. A dynamic driving force in incidence and transmission rates of malaria in Cambodia and the Mekong region is high volume internal mobility and cross-border population.

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